After ACS without PCI, how long should a P2Y12 inhibitor be continued?

• A. 3 months
• B. 6-12 months
• C. 24 months
• D. 4 weeks

Answer: (B)

After ACS managed without PCI, continuing a P2Y12 inhibitor alongside aspirin for about six to twelve months is recommended. This duration strikes a balance between preventing recurrent ischemic events and limiting bleeding risk. Shortening to only a few weeks or months leaves patients at higher risk for recurrence, while extending beyond a year increases bleeding without clear added benefit for those not treated with PCI. Therefore, six to twelve months is the standard target window.