Edoxaban dosing for NVAF and VTE is what on a daily basis?

• A. 60 mg qd
• B. 30 mg qd
• C. 15 mg qd
• D. 90 mg qd

Answer: (A)

Edoxaban is given once daily as the standard dose for both nonvalvular atrial fibrillation and for treatment of venous thromboembolism after initial parenteral therapy. The usual daily amount is 60 mg, taken once each day. A reduced 30 mg daily dose is used only in patients with specific risk factors that increase bleeding risk or reduce drug exposure—such as impaired renal function (creatinine clearance 15–50 mL/min), body weight of 60 kg or less, or concurrent use of certain interacting drugs that affect P-gp. In the majority of patients, the 60 mg daily dose is appropriate, which is why 60 mg once daily is the best answer.