Fondaparinux therapeutic dosing is weight-based and commonly given as which of the following?

• A. 2.5 SQ qd
• B. 1 mg SQ qd
• C. 15 mg SQ qd
• D. 5, 7.5, or 10 mg SQ qd based on weight

Answer: (D)

Fondaparinux dosing for therapeutic anticoagulation is based on body weight to achieve a predictable level of anticoagulation. The standard approach uses three weight-based doses given once daily subcutaneously: 5 mg if under 50 kg, 7.5 mg if 50–100 kg, and 10 mg if over 100 kg. This weight-based scheme is what provides the appropriate anti-Xa activity across different patients without under- or overdosing.

The other options are not used for therapeutic treatment. A daily 2.5 mg dose is a prophylactic level used in some surgical settings, not a therapeutic dose. A 1 mg daily dose and a 15 mg daily dose are not part of the standard fondaparinux therapeutic regimens.