For CrCl <50 mL/min, rivaroxaban dosing is adjusted to which daily amount?

• A. 5 mg
• B. 10 mg
• C. 15 mg
• D. 20 mg

Answer: (B)

Renal function guides rivaroxaban dosing because part of the drug is cleared by the kidneys, so reduced kidney function increases drug exposure and bleeding risk. When CrCl is below 50 mL/min, the dose is reduced to 10 mg once daily to balance safety with efficacy. This reflects adjusting the daily amount to account for decreased clearance. Note that the exact adjustment can differ by indication (for example, some regimens use higher reductions like 15 mg daily in other contexts), so always match the dose to the specific use and patient’s renal function.