Warfarin reversal is achieved with which option in the list?

• A. Direct Factor Xa inhibitors reversal
• B. Dabigatran reversal
• C. Warfarin reversal
• D. Heparin reversal

Answer: (C)

Reversing anticoagulation is specific to the agent involved. Warfarin works by reducing the production of vitamin K–dependent clotting factors (II, VII, IX, X) in the liver. To undo its effect, you don’t use the same reversal strategy as for DOACs or heparin; you replenish those factors and counteract the vitamin K deficiency. That’s why the appropriate approach is Warfarin reversal: administer vitamin K to restore factor production and provide rapid factor replacement with prothrombin complex concentrate (or, if unavailable or less urgent, fresh frozen plasma) to quickly restore the missing factors. In contrast, reversing direct Xa inhibitors would use an Xa-inhibitor antidote (or PCC in some settings), reversing dabigatran uses idarucizumab, and reversing heparin uses protamine. So the option labeled for Warfarin reversal best fits the goal of counteracting the effects of this specific anticoagulant.