Which GP IIb/IIIa inhibitor is not reversible?

Study for the Anticoagulation and ACS Exam with tailored flashcards and multiple choice questions, each featuring hints and detailed explanations. Prepare effectively and ensure success on your exam with confidence!

Multiple Choice

Which GP IIb/IIIa inhibitor is not reversible?

Explanation:
Abciximab is not reversible because it binds to GP IIb/IIIa irreversibly. As a monoclonal antibody Fab fragment, it forms a permanent blockade on the receptor, so the affected platelets remain unable to aggregate until new platelets are produced. In contrast, eptifibatide and tirofiban are reversible, small-molecule inhibitors that dissociate from the receptor as the drug is cleared, so platelet function returns within hours after stopping therapy.

Abciximab is not reversible because it binds to GP IIb/IIIa irreversibly. As a monoclonal antibody Fab fragment, it forms a permanent blockade on the receptor, so the affected platelets remain unable to aggregate until new platelets are produced. In contrast, eptifibatide and tirofiban are reversible, small-molecule inhibitors that dissociate from the receptor as the drug is cleared, so platelet function returns within hours after stopping therapy.

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