Which statement about DOACs compared with warfarin is true?

• A. They require regular INR monitoring
• B. They have more drug interactions
• C. They have no dietary considerations
• D. They have less predictable pharmacodynamics

Answer: (C)

Direct oral anticoagulants do not rely on vitamin K antagonism, so dietary vitamin K intake does not have the same impact as it does with warfarin. Warfarin’s effect is highly sensitive to vitamin K, meaning fluctuations in leafy greens or diet can shift INR and bleeding risk. DOACs provide a more stable anticoagulant effect without needing dietary restrictions, which is why they generally don’t require dietary considerations to be managed.

Keep in mind that while DOACs have fewer drug interactions and don’t require regular INR monitoring, they aren’t completely free of interactions or monitoring considerations, especially with certain drugs or kidney impairment.